Protein Details: Voltage-gated hydrogen channel 1

Protein ID

ICDB_Pro_0992

Protein Name

Voltage-gated hydrogen channel 1

Gene Name

hvcn1

Organism

Xenopus laevis (African clawed frog)

Length

230 amino acids

AlphaFoldDB

AF-Q5M7E9-F1-model_v4.pdb

Function

Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient.

Sequence

MAGCLRHFTSVGDDTKKREWKQEDVEVAYEEPLKNTPHPFIASYSFRGALKWLLSSHKFQIVIICLVILDALFVLVEVLLDLELLAEKVDHIIPEIFHYLSISVLTFFILEIAGKLYAFRLEFFHHKFEVFDAAIVVISFIIDIVYISREDIFNAVGLLILLRLWRVARIVNGVIVSVKTRAEEKMHKLKEQKGSLLEKVAQLEQQCAQQEQEIGRLHKLLQEHNVFPAS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

pancreas

DOI ID

RefSeq

NP_001088875.1; XP_018104580.1; XP_018104589.1; XP_018104596.1; XP_018104605.1; XP_018104612.1